Left click move · attack · talk · pick up (hold to keep moving/attacking)
Right click cast the selected skill at the cursor
Q W E R cast bound skills · click a skill slot to select it for right click
1-4 drink from belt columns · T read Town Portal
I inventory · C character · S skills · L quests · Tab automap
Alt show all item labels, affix tiers and roll ranges
Enter chat (/players, /kick name) · Mouse wheel zoom · M mute · Esc close / menu
NPCs speak in keywords: click the [bracketed] words or type your own.